Accessing FcLigand features through a web browser: The performance of calculations and graphical rendering was evaluated in a client-server web architecture using the Blazor framework (open-source framework from Microsoft to create web user interfaces based on components using C# and HTML). Blazor leverages WebAssembly technology developed by the World Wide…
Promoting women’s rights with Cité des Droits des Femmes association: In 2023 we were proud to initiate activities at Felix Concordia to promote human rights, which is one of the seven core subjects of the ISO 26000 international standard for social responsibility, a CSR guideline. We became the first corporate…
FcBioisostere new graphical features to better explore bioisosteric PDB based pairs: This year we extanded the FcBioisostere software to better sort the precalculated 3D bioisosteric pairs extracted by our application from the PDB Protein Data Bank. Same topological pairs are now grouped together to help users assess a statistical suitability…
Designing protocols with a workflow user interface: In order to faster design new protocols for users in our C2P Chemo-Proteomic Platform, we investigated technical solutions to provide a sketcher to users to design predictive protocols similar to a workflow. FcPipeline our new module under development provides a full set of…
Proof Of Concepts to annotate protein surfaces and generate drug candidates: Since the beginning of the COVID-19 pandemic crisis, the scientific community has generated an amazing amount of data especially in structural biology with more proteins together with cocrystallised ligands of fragment probes. We ran our 3D intermolecular surface miner…
Code standardization in C# for agile developments: To streamline our software development processes, we decided this year to migrate some of our components to C#, our primary programming language. By bypassing dynamic serialization, we gain advantages in speed, memory usage, and enable full polymorphism for data types throughout the code.…
Poster presentation at the 2017 Groupe de Graphisme & Modélisation Moléculaire conference (Reims, France): Fast software development in drug design with the C2P-API toolkit : Rebuilding ligand bound conformation from PDB subpocket superpositions Abstract: Literature in the FBDD field reported cases where the binding location and orientation of small co-crystallized…
Pre-release of the Felix Concordia cheminformatics Advanced Programming Interface: Today July 1st 2013, Felix Concordia is providing access to the SupBiotech engineer school (http://www.supbiotech.fr/) on an Advanced Programming Interface dedicated to cheminformatics. This set of documented informatics classes represents a consistent architecture to develop on demand new predictive methods/procedures on ligands…
The C2P Chemo-Proteomic Platform initiative to address new challenges in drug design: On July 1st 2013, MEDIT and Felix Concordia have launched the C2P Chemo-Protein Platform initiative to provide a complete software solution to better mine altogether biostructures, structure activities and chemical libraries at PDB, Pubchem and multi-million compound levels.…
First sale of FcBioisostere software: On November 11th 2011, the Center for Biophysical Sciences and Engineering of the University of Alabama acquired multiple software licenses to use FcBioiostere on the whole campus. FC-Bioisostere opens access to 3D bioisosteric replacement onto a lead molecule to find chemical groups having similar 3D…
